Best Endpoint Protection Solutions For MSP/MSSPs In 2025

In the complex and rapidly evolving world of cybersecurity, Managed Service Providers (MSPs) and Managed Security Service Providers (MSSPs) are on the front lines, defending a wide array of clients from relentless cyber threats.

The most critical point of defense in this battle is the endpoint the laptops, desktops, and mobile devices that are the primary entry points for attackers.

Without a robust and scalable endpoint protection solution, MSPs and MSSPs risk not only their clients’ data and business continuity but also their own reputation.

The market for endpoint protection solutions for MSPs and MSSPs is highly competitive, with vendors constantly innovating to provide the best tools for detection, response, and management.

For 2025, the ideal solution must go beyond simple antivirus, offering advanced capabilities like Endpoint Detection and Response (EDR), threat hunting, and a multi-tenant management console designed specifically for the needs of a service provider.

This article explores the Best Endpoint Protection Solutions for MSPs/MSSPs in 2025, providing a detailed analysis of the top contenders based on their features, specifications, and suitability for the service provider model.

Why MSPs And MSSPs Need Specialized Endpoint Solutions

MSPs and MSSPs face unique challenges that require more than a standard enterprise-grade security product:

Multi-Tenancy and Scalability: A solution must be built for multi-tenancy, allowing a single pane of glass to manage hundreds or even thousands of client environments efficiently.

Operational Efficiency: The solution needs to be low-touch and easy to deploy, manage, and update, as service providers often operate with lean security teams.

Profitability: Pricing models must be flexible, often based on monthly usage, to align with the service provider’s revenue structure.

Integrated Threat Response: The ability to not only detect but also automatically respond to and remediate threats is crucial for reducing manual effort and improving response times.

Visibility and Reporting: Comprehensive and customizable reporting is essential for demonstrating value to clients and meeting compliance requirements.

The products on this list are all designed with these specific requirements in mind, offering a blend of powerful technology and a service provider-friendly operational model.

Comparison Table: Best Endpoint Protection Solutions For MSP/MSSPs In 2025

Company	EDR/MDR Included	Multi-Tenant Console	AI/ML-Driven Threat Prevention	Behavioral Analysis	Automated Remediation	Flexible Pricing
Sophos Intercept X	✅ Yes	✅ Yes	✅ Yes	✅ Yes	✅ Yes	✅ Yes
Huntress	✅ Yes	✅ Yes	✅ Yes	✅ Yes	✅ Yes	✅ Yes
SentinelOne Singularity	✅ Yes	✅ Yes	✅ Yes	✅ Yes	✅ Yes	✅ Yes
CrowdStrike Falcon	✅ Yes	✅ Yes	✅ Yes	✅ Yes	✅ Yes	✅ Yes
Check Point	✅ Yes	✅ Yes	✅ Yes	✅ Yes	✅ Yes	✅ Yes
Bitdefender	✅ Yes	✅ Yes	✅ Yes	✅ Yes	✅ Yes	✅ Yes
Microsoft Defender	✅ Yes	✅ Yes	✅ Yes	✅ Yes	✅ Yes	❌ No
ESET Protect	❌ No	✅ Yes	✅ Yes	✅ Yes	✅ Yes	✅ Yes
Trend Micro	✅ Yes	✅ Yes	✅ Yes	✅ Yes	✅ Yes	✅ Yes
Blackpoint Cyber	✅ Yes	✅ Yes	✅ Yes	✅ Yes	✅ Yes	✅ Yes

The Top 10 Best Endpoint Protection Solutions For MSP/MSSPs In 2025

Here is a detailed analysis of the top 10 endpoint protection solutions for service providers in 2025.

1. Sophos Intercept X

Why We Picked It:

Sophos Intercept X is a top contender for MSPs and MSSPs because of its exceptional blend of advanced security features and a partner-centric management platform.

The Sophos Central console is arguably one of the most intuitive and comprehensive dashboards for managing multiple client environments.

The inclusion of features like anti-ransomware rollback, deep learning for malware prevention, and synchronized security makes it a powerful, all-in-one solution that reduces the number of tools an MSP needs to manage.

Specifications:

Sophos Intercept X provides a full suite of endpoint protection features, including next-gen antivirus (NGAV), Endpoint Detection and Response (EDR), Managed Detection and Response (MDR), and ransomware rollback.

The solution is managed through a single cloud-based console, Sophos Central, which offers multi-tenant management, flexible licensing, and integrated reporting.

Reason to Buy:

If you are an MSP or MSSP seeking a reliable, feature-rich, and easy-to-manage endpoint protection solution, Sophos Intercept X is an excellent choice.

Its deep-learning AI for predictive threat prevention and the powerful anti-ransomware feature offer a high level of security, while the intuitive multi-tenant console streamlines operations and improves efficiency.

Features:

• Deep Learning AI: Predictive threat prevention that identifies both known and unknown malware.
• CryptoGuard: An advanced anti-ransomware technology that rolls back the effects of a ransomware attack.
• Synchronized Security: Integrates with other Sophos products (like firewalls) for a unified security posture.
• Multi-tenant Sophos Central Console: A single pane of glass for managing all client environments.
• Threat Analysis and EDR: Provides visibility into threats with guided investigations to identify the root cause.

Pros:

• Robust, all-in-one security suite.
• Excellent multi-tenant management console.
• Strong partner program and channel support.
• Proven effectiveness against ransomware.

Cons:

• Can be more expensive than some competitors.
• The full suite of features might be overkill for some smaller clients.

✅ Best For: MSPs and MSSPs that want a powerful, all-in-one security platform with a highly intuitive and partner-friendly management console.

🔗 Try Sophos Intercept X here → Sophos Official Website

2. Huntress

Why We Picked It:

Huntress is a game-changer for MSPs because it fills a critical gap in the security stack: human-powered threat hunting.

While many solutions offer EDR, Huntress provides a dedicated team of human threat hunters who actively look for persistent footholds, which are signs of an advanced attack.

This is particularly valuable for MSPs who may not have the in-house expertise or resources to perform these tasks themselves.

Their straightforward, no-nonsense approach and simple pricing model make them a perfect fit for the service provider community.

Specifications:

Huntress specializes in Managed Detection and Response (MDR), threat hunting, and automated remediation.

It works alongside an organization’s existing endpoint protection solution, acting as a force multiplier.

The platform focuses on finding hidden threats, such as backdoors, persistence mechanisms, and advanced malware.

Reason to Buy:

If you are an MSP that wants to offer a high-value, proactive security service without the overhead of hiring and training a full-time SOC team, Huntress is an ideal solution.

Their human-led approach provides a level of protection that automated tools cannot match, making it a compelling upsell to clients who are serious about their security.

Features:

• Human-Powered Threat Hunting: A team of security researchers actively hunts for threats in your clients’ environments.
• Managed Detection and Response (MDR): Provides 24/7 monitoring and response to security incidents.
• Persistent Foothold Detection: Finds and removes backdoors and other persistent malware.
• Simple Pricing Model: Flat, per-endpoint pricing designed for MSP profitability.
• Automated Remediation: Provides one-click remediation of detected threats.

Pros:

• Fills a critical gap in the security stack.
• Human-led analysis provides superior threat detection.
• Simple and transparent pricing.
• Acts as a true extension of the MSP’s team.

Cons:

• Not a full replacement for a traditional antivirus solution.
• Relies on a subscription to their managed service.

✅ Best For: MSPs and MSSPs that want to add a human-powered, proactive threat hunting and MDR service to their security stack without hiring a full SOC team.

🔗 Try Huntress here → Huntress Official Website

3. SentinelOne Singularity

Why We Picked It:

SentinelOne’s Singularity platform is a top choice for service providers because of its focus on autonomous, AI-driven protection.

The platform’s ability to automatically prevent, detect, and respond to threats at machine speed is a huge advantage for MSPs who need to manage a large number of endpoints with limited resources.

Its unified approach, which combines EDR, threat intelligence, and a single agent, simplifies management and reduces the operational burden on the service provider.

Specifications:

SentinelOne’s Singularity platform provides a unified view of endpoints, workloads, and identity.

It offers AI-powered threat prevention, detection, and response, as well as threat hunting, IoT security, and cloud workload protection.

The platform is managed through a single, multi-tenant console and provides autonomous remediation capabilities.

Reason to Buy:

If you are an MSP or MSSP looking for a highly automated, AI-driven endpoint solution that can provide fast and effective protection with minimal human intervention, SentinelOne is a compelling option.

Its autonomous response capabilities are perfect for environments where threats need to be neutralized immediately, without waiting for a human analyst.

Features:

• Autonomous AI: Uses behavioral AI to prevent, detect, and respond to threats in real-time.
• Single Agent: A single, lightweight agent provides comprehensive protection across various operating systems.
• Storyline™ Technology: Automatically stitches together events into a single, comprehensive “story” of an attack.
• Active EDR: Provides autonomous remediation and rollback of malicious changes.
• Flexible Deployment: Cloud-native platform with flexible deployment options.

Pros:

• Highly effective at stopping attacks autonomously.
• Lightweight agent with low performance impact.
• Unified platform simplifies management.
• Strong in-house research and threat intelligence.

Cons:

• Advanced features can have a steep learning curve.
• Pricing can be complex for some MSPs.

✅ Best For: Forward-thinking MSPs and MSSPs who want a highly automated, AI-driven solution that provides fast, autonomous protection and simplifies management.

🔗 Try SentinelOne Singularity here → SentinelOne Official Website

4. CrowdStrike Falcon

Why We Picked It:

CrowdStrike Falcon is a gold standard in the cybersecurity industry, and its MSSP program is tailored to allow service providers to leverage its powerful capabilities.

We chose it for its best-in-class threat detection, leveraging a massive threat intelligence network and a highly effective, cloud-native architecture.

The Falcon platform’s ability to provide unparalleled visibility and proactive threat hunting makes it a top choice for MSSPs who offer high-end, human-led security services.

Specifications:

CrowdStrike Falcon provides a unified platform for endpoint security, threat intelligence, and proactive threat hunting.

Its key modules include Falcon Prevent (NGAV), Falcon Insight (EDR), and Falcon OverWatch (Managed Threat Hunting). The solution is managed through a multi-tenant cloud console, with a single, lightweight agent for deployment.

Reason to Buy:

If you are an MSSP that wants to provide premium, intelligence-driven endpoint security services and differentiate your offering with a top-tier brand, CrowdStrike Falcon is an excellent choice.

Its powerful EDR capabilities and the option to add Falcon OverWatch for human-led threat hunting allow you to offer a superior level of protection to your clients.

Features:

• Single, Lightweight Agent: Deploys in minutes and has a minimal performance impact.
• Cloud-Native Architecture: Provides instant scalability and real-time protection.
• Falcon OverWatch: A dedicated team of human threat hunters that proactively hunts for threats.
• Massive Threat Intelligence: Leverages real-time data from a global network of sensors.
• Automated Remediation: Provides automated response and remediation for detected threats.

Pros:

• Market leader with a stellar reputation.
• Unparalleled threat detection and response capabilities.
• Single, lightweight agent is easy to deploy.
• Dedicated MSSP program.

Cons:

• Can be one of the most expensive options.
• The full suite of features may be complex for smaller MSPs to manage.

✅ Best For: MSSPs and larger MSPs who want to offer a premium, intelligence-driven endpoint protection service with a top-tier brand.

🔗 Try CrowdStrike Falcon here → CrowdStrike Official Website

5. Check Point

Why We Picked It:

We chose Check Point Harmony Endpoint for its comprehensive, consolidated approach to endpoint security.

As part of the Infinity platform, it integrates with Check Point’s broader security solutions, providing a unified threat prevention and management system.

This is particularly beneficial for MSPs and MSSPs who want to offer a multi-layered security stack from a single vendor, simplifying procurement, integration, and management.

Specifications:

Check Point Harmony Endpoint provides a full suite of security features, including NGAV, EDR, anti-ransomware, anti-phishing, and web protection.

It is managed through a single, multi-tenant cloud console and can be easily deployed and scaled.

Reason to Buy:

If you are an MSP or MSSP looking to offer a consolidated, multi-layered security solution from a single vendor, Check Point Harmony Endpoint is a strong choice.

Its ability to integrate with other Check Point products and provide a single pane of glass for management simplifies operations and reduces the complexity of managing multiple security tools.

Features:

• Consolidated Protection: Combines NGAV, EDR, and other security layers into a single agent.
• Anti-Ransomware: Advanced behavioral analysis to stop ransomware in its tracks.
• Anti-Phishing: Proactive protection against phishing attacks across email and web.
• Unified Management: A single, multi-tenant console for managing all client security.
• Endpoint Forensics: Provides in-depth analysis of security incidents.

Pros:

• Consolidated, all-in-one solution.
• Integrates with a broader security ecosystem.
• Strong protection against a variety of threats.
• Multi-tenant management for service providers.

Cons:

• The full Infinity platform can be complex.
• Documentation can be sparse, requiring reliance on support.

✅ Best For: MSPs and MSSPs who prefer a single-vendor solution and want to provide a consolidated, multi-layered security offering to their clients.

🔗 Try Check Point Harmony Endpoint here → Check Point Official Website

6. Bitdefender

Why We Picked It:

Bitdefender GravityZone is a top pick due to its high-performance security engine and its flexible, MSP-friendly pricing model.

Its layered security approach is highly effective at stopping both known and unknown threats with a low performance impact on endpoints.

The platform’s dynamic monthly licensing and aggregated tier-based pricing make it highly profitable for service providers, allowing them to scale their business without being locked into rigid contracts.

Specifications:

Bitdefender GravityZone for MSPs provides comprehensive endpoint protection, including NGAV, EDR, anti-ransomware, and advanced threat security. It is managed through a single cloud console with a flexible, usage-based licensing model designed for MSPs.

Reason to Buy:

If you are an MSP looking for a highly effective, low-overhead endpoint security solution with a flexible and profitable pricing model, Bitdefender GravityZone is an excellent choice.

Its combination of powerful protection and a partner-centric business model makes it a strong contender in the MSP space.

Features:

• Multilayered Security: Combines machine learning, behavioral analysis, and exploit defense.
• Lightweight Agent: Minimal performance impact on endpoints.
• GravityZone Cloud Console: A single, multi-tenant console for managing all clients.
• Flexible Licensing: Dynamic, usage-based monthly licensing.
• Aggregated Pricing Tiers: Pricing scales based on total endpoints across all clients.

Pros:

• High-performance security engine.
• Extremely MSP-friendly pricing model.
• Effective against a wide range of threats.
• Low overhead and easy to manage.

Cons:

• Some advanced features may require additional add-ons.
• UI can be less intuitive than some competitors.

✅ Best For: MSPs that prioritize a highly effective security engine and a flexible, profitable, usage-based licensing model.

🔗 Try Bitdefender GravityZone MSP here → Bitdefender Official Website

7. Microsoft Defender

Why We Picked It:

Microsoft Defender for Endpoint is on this list for its sheer power and deep integration with the Microsoft ecosystem.

For MSPs and MSSPs managing a large number of clients who are already heavily invested in Microsoft 365, Defender for Endpoint offers a unified security experience that is seamless to deploy and manage.

Its built-in nature and continuous updates make it a robust and often cost-effective solution for a large segment of the market.

Specifications:

Microsoft Defender for Endpoint offers a full suite of endpoint security features, including NGAV, EDR, threat intelligence, and automated investigation and response (AIR).

It is managed through the Microsoft 365 Defender portal and provides multi-tenancy capabilities for service providers.

Reason to Buy:

If your client base is primarily using Windows and Microsoft 365, leveraging Microsoft Defender for Endpoint can provide a high-level of protection with minimal friction.

Its deep integration with other Microsoft security tools creates a powerful, unified security platform, reducing the need for multiple vendors and simplifying management.

Features:

• Seamless Integration: Deeply integrated with Windows OS and Microsoft 365.
• Automated Investigation and Response (AIR): Automatically investigates and remediates threats.
• Threat and Vulnerability Management: Provides real-time visibility into vulnerabilities.
• Centralized Management: Managed through the Microsoft 365 Defender portal.
• Rich Threat Intelligence: Leverages Microsoft’s massive threat intelligence network.

Pros:

• Extremely powerful and comprehensive.
• Deep integration with the Microsoft ecosystem.
• Often included in Microsoft 365 licenses, potentially reducing costs.
• No agent to install for Windows 10/11.

Cons:

• Management can be complex, especially for non-Microsoft environments.
• Multi-tenancy capabilities are not as mature or easy to use as dedicated MSP solutions.
• Can be challenging to manage on non-Windows endpoints.

✅ Best For: MSPs and MSSPs who primarily manage Windows environments and want to leverage their clients’ existing Microsoft 365 licenses for a powerful, integrated security solution.

🔗 Try Microsoft Defender for Endpoint here → Microsoft Official Website

8. ESET Protect

Why We Picked It:

ESET Protect is on this list because of its exceptional balance of strong security and a minimal system footprint.

For MSPs managing a variety of client environments, including older hardware, ESET’s lightweight agent ensures that security does not come at the cost of performance.

Its multi-layered approach provides reliable protection without being overly complex, and its MSP-friendly management console makes it easy to deploy and manage.

Specifications:

ESET Protect offers a modular platform with multiple layers of protection, including NGAV, behavioral analysis, and fileless attack detection.

It is managed through a multi-tenant cloud console, ESET Protect, and offers flexible licensing options for service providers.

Reason to Buy:

If you are an MSP looking for a solution that provides strong, reliable protection without impacting endpoint performance, ESET Protect is an ideal choice.

Its lightweight agent and multi-layered security approach make it suitable for a wide range of clients, from small businesses with older hardware to larger organizations with complex environments.

Features:

• Minimal System Impact: Lightweight agent that doesn’t slow down endpoints.
• Multi-layered Protection: Combines multiple detection technologies for comprehensive security.
• LiveGuard Advanced Threat Defense: Sandbox analysis for advanced threats.
• Flexible Deployment: Cloud and on-premises deployment options.
• Multi-tenant Console: ESET Protect provides centralized management for all clients.

Pros:

• Excellent performance and a low system footprint.
• Proven and reliable threat detection.
• MSPs-friendly management console.
• Flexible and modular licensing.

Cons:

• The EDR capabilities are not as advanced as some competitors.
• Reporting can be less robust.

✅ Best For: MSPs who prioritize a lightweight, high-performance endpoint solution that won’t slow down their clients’ devices, especially those with older or less powerful hardware.

🔗 Try ESET Protect here → ESET Official Website

9. Trend Micro

Why We Picked It:

Trend Micro Vision One is a top pick for MSSPs because it’s more than just an endpoint solution it’s an XDR platform.

We chose it for its ability to provide centralized visibility and control across the entire IT estate, correlating alerts and events from endpoints, email, cloud workloads, and the network.

This holistic view is crucial for MSSPs who need to identify and respond to complex, multi-stage attacks that span across different environments.

Specifications:

Trend Micro Vision One provides XDR capabilities, including endpoint security, email security, network security, and cloud workload protection.

It uses a single console to provide centralized visibility and control, with AI-powered threat detection and automated response capabilities.

Reason to Buy:

If you are an MSSP that offers comprehensive security services and needs a platform that can provide a holistic view of a client’s security posture, Trend Micro Vision One is an excellent choice.

Its XDR capabilities allow you to move beyond endpoint protection and provide a higher-value, more integrated service that can effectively stop sophisticated attacks.

Features:

• Extended Detection and Response (XDR): Correlates data from multiple security layers for a holistic view.
• AI-Powered Threat Detection: Uses advanced AI to identify and stop threats.
• Unified Security Platform: A single console for managing endpoints, email, and cloud security.
• Automated Response: Automates threat investigation and remediation.
• Attack Surface Risk Management: Provides insights into vulnerabilities and security gaps.

Pros:

• Provides a holistic view of security risks.
• Strong XDR capabilities.
• Unified management console simplifies operations.
• Backed by a reputable, long-standing security vendor.

Cons:

• Can be complex for smaller MSPs to fully utilize.
• Requires a broader service offering to justify the platform’s cost.

✅ Best For: MSSPs and large MSPs who want to provide a comprehensive, multi-layered security service that includes XDR capabilities.

🔗 Try Trend Micro Vision One here → Trend Micro Official Website

10. Blackpoint Cyber

Why We Picked It:

Blackpoint Cyber is a top pick because it is a company that truly understands the MSP business model and security needs.

Their platform is purpose-built for MSPs, offering not just a tool but a full MDR service backed by a live security operations center (SOC).

This provides MSPs with a high-value, easy-to-manage security solution that can effectively respond to advanced threats in real-time. Their pricing and partner support are also tailored to the MSP community.

Specifications:

Blackpoint Cyber provides a full suite of security services, including a proprietary MDR platform, a live SOC, and a multi-tenant management console.

It offers protection against ransomware, advanced malware, and other threats through a combination of automated and human-led detection and response.

Reason to Buy:

If you are an MSP that wants to offer a high-end, human-powered MDR service to your clients without the complexity of managing a traditional EDR solution, Blackpoint Cyber is an excellent choice.

Their all-in-one platform and dedicated SOC team allow you to provide a high level of security with minimal operational overhead.

Features:

• Managed Detection and Response (MDR): 24/7 monitoring and response by a live SOC team.
• Purpose-Built for MSPs: The platform and pricing are designed specifically for the service provider community.
• Real-Time Response: The SOC team can respond to and neutralize threats in real-time.
• Single-Pane-of-Glass: A multi-tenant console for managing all clients.
• Integrated Security: Combines various security layers for comprehensive protection.

Pros:

• Built from the ground up for MSPs.
• Human-led MDR provides superior threat detection.
• Simple and transparent pricing model.
• Strong partner support and community.

Cons:

• Less customizable than some enterprise-grade solutions.
• Less well-known brand than competitors like CrowdStrike.

✅ Best For: MSPs looking for a comprehensive, all-in-one security solution with a built-in MDR service and a partner-centric business model.

🔗 Try Blackpoint Cyber here → Blackpoint Cyber Official Website

Conclusion

Choosing the right endpoint protection solution is one of the most strategic decisions an MSP or MSSP can make in 2025.

The right solution not only secures your clients’ environments but also directly impacts your operational efficiency and profitability.

While some vendors excel in raw power and advanced features, others stand out for their partner-centric pricing, ease of use, and human-led services.

The market offers a wide range of options, from all-in-one platforms like Sophos Intercept X and Check Point Harmony Endpoint to specialized, human-powered services like Huntress and Blackpoint Cyber.

For those who need a highly automated solution, SentinelOne and CrowdStrike are top-tier choices. For those managing a primarily Microsoft-based environment, Microsoft Defender for Endpoint is a strong contender.

Ultimately, the best solution will be the one that aligns with your business model, client base, and the level of security services you aim to provide.

By carefully evaluating the options presented here, you can make an informed decision that will secure your clients and strengthen your business for years to come.